Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A0GU
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| Drug Name |
E-52862
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| Synonyms |
S1RA; UNII-ZW18DSD1H4; ZW18DSD1H4; GTPL10431; MR309; BCP08990; AOB87704; sigma 1 receptor antagonist (S1RA); ZINC95000617; s6754; BDBM50396352; AKOS026750239; SB17181; MCULE-6623106441; CS-2187; compound 28 [PMID: 22784008]; NCGC00371119-04; DA-40938; HY-18099; FT-0700391; E52862; A12504; Q7388203
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| Drug Type |
Small molecular drug
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| Indication | Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [1] | |
| Therapeutic Class |
Antiviral Agents
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| Structure |
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Download2D MOL |
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| Formula |
C20H23N3O2
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| Canonical SMILES |
CC1=CC(=NN1C2=CC3=CC=CC=C3C=C2)OCCN4CCOCC4
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| InChI |
1S/C20H23N3O2/c1-16-14-20(25-13-10-22-8-11-24-12-9-22)21-23(16)19-7-6-17-4-2-3-5-18(17)15-19/h2-7,14-15H,8-13H2,1H3
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| InChIKey |
DGPGXHRHNRYVDH-UHFFFAOYSA-N
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| CAS Number |
CAS 878141-96-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN opioid receptor sigma 1 (OPRS1) | Target Info | Antagonist | [2] |
| References | Top | |||
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| REF 1 | Synthesis and Biological Evaluation of the 1-arylpyrazole Class of (1) Receptor Antagonists: Identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J Med Chem. 2012 Oct 11;55(19):8211-24. | |||
| REF 2 | A SARS-CoV-2 protein interaction map reveals targets for drug repurposing | |||
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