Drug Information
Drug General Information | Top | |||
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Drug ID |
D0A2OW
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Former ID |
DNC001068
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Drug Name |
Otenzepad
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Synonyms |
Otenzepad; AF-DX 116; 102394-31-0; AF-DX-116; 11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one; UNII-WW6A9TFL2C; UNII-SX2WTG9R3Z; WW6A9TFL2C; SX2WTG9R3Z; 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE; BRN 4212983; CHEMBL17045; NSC664529; 100158-38-1; NCGC00025002-02; DSSTox_RID_81048; DSSTox_CID_25674; DSSTox_GSID_45674; 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)
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Drug Type |
Small molecular drug
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Indication | Heart failure [ICD-11: BD10-BD13; ICD-10: I50, I50.9; ICD-9: 428] | Discontinued in Phase 2 | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C24H31N5O2
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Canonical SMILES |
CCN(CC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4
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InChI |
1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
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InChIKey |
UBRKDAVQCKZSPO-UHFFFAOYSA-N
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CAS Number |
CAS 102394-31-0
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PubChem Compound ID | ||||
PubChem Substance ID |
239489, 510727, 5530915, 10234472, 11426578, 12013665, 14929469, 26719787, 26752073, 44436806, 46386986, 47423785, 47499112, 47572939, 48242935, 49681762, 50034619, 50917362, 57338297, 85229917, 85788636, 91746553, 92098548, 92308468, 103181030, 103929232, 104379928, 124659038, 124886981, 129345351, 134340056, 134340317, 135066279, 135132787, 135649900, 135698213, 139732225, 144204493, 162022222, 162022958, 163122876, 170466332, 170485721, 172080425, 172657833, 179149480, 179295983, 184536610, 184547112, 204380666
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ChEBI ID |
CHEBI:111174
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References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 309). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001216) | |||
REF 3 | Beneficial effect of muscarinic-2 antagonist on dilated cardiomyopathy induced by autoimmune mechanism against muscarinic-2 receptor. J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S43-9. |
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