Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A5FM
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| Former ID |
DAP001056
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| Drug Name |
Nitric Oxide
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| Synonyms |
Nitric oxide; nitric oxide; nitrogen monoxide; Mononitrogen monoxide; 10102-43-9; nitrogen monooxide; nitrogen protoxide; nitrosyl; Nitrosyl radical; EDRF; CHEBI:16480; endothelium-derived relaxing factor; monoxyde d'azote; oxoazanyl; oxyde azotique; oxido nitrico; Stickstoffmonoxid; Nitric oxide trimer; monoxido de nitrogeno; Stickstoff(II)-oxid; Nitric oxide (JAN); INOmax (TN); oxido de nitrogeno(II); Nitrosoradical; [NO]; oxidonitrogen(); Nitrogen(II) oxide; OHM 11771; AC1L3QHF; Nitric oxide, 985%; DTXSID1020938; CHEMBL1200689; CTK0H7679; ()NO; HNO; INOmax; Nitrosyl; Nitroxyl; Oxoazanyl; Stickmonoxyd; Endogenous Nitrate Vasodilator; Monoxido de nitrogeno; Nitrogen monooxide; Nitrogen monoxide; Nitrosyl hydride; Nitroxide radical; Oxido nitrico; Oxyde azotique; Oxyde nitrique [French]; Stickmonoxyd [German]; Bioxyde d'azote; Bioxyde d'azote [French]; Endothelium-Derived Nitric Oxide; Monoxide, Mononitrogen; Monoxide, Nitrogen; Monoxyde d'azote; NITRIC-OXIDE; NO(); Nitrate Vasodilator, Endogenous; Nitric Oxide, Endothelium Derived; Nitric oxide 10% by volume or more; Nitric oxide, compressed [UN1660] [Poison gas]; Nitrogen oxide (NO); Oxide, Nitric; Oxido de nitrogeno(II); Oxidonitrogen(); Vasodilator, Endogenous Nitrate; Nitric Oxide, Endothelium-Derived; Nitrosyl hydride ((NO)H); Endothelium-derived relaxing factor (EDRF)
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| Drug Type |
Small molecular drug
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| Indication | Respiratory failure [ICD-11: CB41; ICD-10: J96; ICD-9: 518.81] | Approved | [1], [2] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 3 | [1], [3] | ||
| Tinea pedis [ICD-11: 1F28.2; ICD-10: B35.3] | Discontinued in Phase 2 | [4] | ||
| Therapeutic Class |
Bronchodilator Agents
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| Company |
NB therapeutics; University of Akron
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| Structure |
 |
Download2D MOL |
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| Formula |
NO
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| Canonical SMILES |
[N]=O
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| InChI |
1S/NO/c1-2
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| InChIKey |
MWUXSHHQAYIFBG-UHFFFAOYSA-N
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| CAS Number |
CAS 10102-43-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3009, 3815, 584758, 584760, 585304, 612541, 819430, 819437, 823106, 825225, 827786, 827830, 829083, 829196, 830346, 831905, 832739, 832741, 832746, 832749, 835684, 835924, 835946, 835951, 837432, 837589, 838043, 838516, 838735, 838738, 838741, 841103, 854516, 854518, 6435917, 6436059, 6436465, 7847142, 8009073, 8024763, 8025088, 10248789, 10322712, 10502255, 11532572, 11532575, 11533089, 11538857, 11538865, 14715948
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| ChEBI ID |
CHEBI:16480
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| ADReCS Drug ID | BADD_D01574 | |||
| SuperDrug ATC ID |
R07AX01
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| SuperDrug CAS ID |
cas=010102439
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Guanylate cyclase (GC) | Target Info | Stimulator | [5] |
| Soluble guanylate cyclase (GCS) | Target Info | Stimulator | [6] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2509). | |||
| REF 2 | Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin Emerg Drugs. 2007 Sep;12(3):461-77. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024215) | |||
| REF 5 | Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201. | |||
| REF 6 | Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol. 1996 May 30;77(13):2C-7C. | |||
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