Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A7SR
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| Former ID |
DNC014235
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| Drug Name |
H-Leu-Phe-NH2
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| Synonyms |
Leucyl-phenylalanine amide; H-Leu-Phe-NH2; L-Leucyl-L-phenylalaninamide; 38678-60-3; CHEMBL590518; Leu-phe-NH2; AC1MIYXY; SCHEMBL2184039; L-Phenylalaninamide, L-leucyl-; DTXSID30191975; HVNQCDIUFGAINF-STQMWFEESA-N; ZINC1605748; BDBM50308392; AKOS027447855; (2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-3-phenylpropanamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H23N3O2
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| Canonical SMILES |
CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)N)N
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| InChI |
1S/C15H23N3O2/c1-10(2)8-12(16)15(20)18-13(14(17)19)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H2,17,19)(H,18,20)/t12-,13-/m0/s1
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| InChIKey |
HVNQCDIUFGAINF-STQMWFEESA-N
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| CAS Number |
CAS 38678-60-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Substance-P receptor (TACR1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Measles | ||||
| Panther Pathway | CCKR signaling map ST | |||
| Reactome | G alpha (q) signalling events | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Spinal Cord Injury | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem. 2010 Mar 25;53(6):2383-9. | |||
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