Drug Information
Drug General Information | Top | |||
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Drug ID |
D0A8EK
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Former ID |
DIB018866
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Drug Name |
APNEA
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Synonyms |
89705-21-5; CHEMBL1256714; N-[2-(4-Aminophenyl)ethyl]-adenosine; SMR000326823; MLS000859964; MLS002153195; SCHEMBL1230660; DTXSID40433272; XTPOZVLRZZIEBW-SCFUHWHPSA-N; HMS2233B08; ZINC8660412; BDBM50453442; AKOS030526973; CS-4923; Adenosine, N6-2-(4-aminophenyl)ethyl; HY-18687; LS-15099; N6-2-(4-Aminophenyl)ethyladenosine, >
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C18H22N6O4
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Canonical SMILES |
C1=CC(=CC=C1CCNC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O)N
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InChI |
1S/C18H22N6O4/c19-11-3-1-10(2-4-11)5-6-20-16-13-17(22-8-21-16)24(9-23-13)18-15(27)14(26)12(7-25)28-18/h1-4,8-9,12,14-15,18,25-27H,5-7,19H2,(H,20,21,22)/t12-,14-,15-,18-/m1/s1
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InChIKey |
XTPOZVLRZZIEBW-SCFUHWHPSA-N
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CAS Number |
CAS 89705-21-5
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Adenosine A2b receptor (ADORA2B) | Target Info | Agonist | [2] |
KEGG Pathway | Rap1 signaling pathway | |||
Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Vascular smooth muscle contraction | ||||
Alcoholism | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathwhiz Pathway | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine | |||
Pathway Interaction Database | C-MYB transcription factor network | |||
Reactome | Adenosine P1 receptors | |||
G alpha (s) signalling events | ||||
Surfactant metabolism | ||||
WikiPathways | Nucleotide GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 417). | |||
REF 2 | Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors. Biochem Pharmacol. 1999 Jan 1;57(1):65-75. |
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