Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A8SI
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| Drug Name |
Lactam derivative 4
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| Synonyms |
PMID25470667-Compound-Figure5-7
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| Drug Type |
Small molecular drug
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| Company |
MERCK SHARP & DOHME CORP. GRAHAM, Thomas SHEN, Dong-Ming NARGUND, Ravi, P. WU, Zhicai LIU, Wenshen
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| Structure |
 |
Download2D MOL |
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| Formula |
C29H40N4O4
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| Canonical SMILES |
CCCCCCCCC1=NC(=C2C(=N1)OCCN(C2=O)C3=CC=C(C=C3)C4CCC(CC4)CC(=O)O)N
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| InChI |
1S/C29H40N4O4/c1-2-3-4-5-6-7-8-24-31-27(30)26-28(32-24)37-18-17-33(29(26)36)23-15-13-22(14-16-23)21-11-9-20(10-12-21)19-25(34)35/h13-16,20-21H,2-12,17-19H2,1H3,(H,34,35)(H2,30,31,32)
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| InChIKey |
AGYANLSXRVBLRK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Diacylglycerol acyltransferase 1 (DGAT1) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Retinol metabolism | ||||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Statin Pathway | ||||
| Triacylglyceride Synthesis | ||||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. | |||
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