Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0A8UP
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| Former ID |
DIB018036
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| Drug Name |
PMID15026062C41
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| Synonyms |
GTPL6702; BDBM50142719
Click to Show/Hide
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| Drug Type |
Small molecular drug
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| Indication | Pancreatitis [ICD-11: DC31-DC34] | Clinical trial | [1], [2] | |
| Structure |
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Download2D MOL
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| Formula |
C22H33N3O4
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| Canonical SMILES |
CC(C)(C)C1CCC(CC1)C(=O)NC2=CC=C(C=C2)OC(=O)NN3CCOCC3
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| InChI |
1S/C22H33N3O4/c1-22(2,3)17-6-4-16(5-7-17)20(26)23-18-8-10-19(11-9-18)29-21(27)24-25-12-14-28-15-13-25/h8-11,16-17H,4-7,12-15H2,1-3H3,(H,23,26)(H,24,27)
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| InChIKey |
XSLDWDIQZLTRHG-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hormone sensitive lipase (LIPE) | Target Info | Inhibitor | [1] |
| BioCyc | Triacylglycerol degradation | |||
| KEGG Pathway | cAMP signaling pathway | |||
| AMPK signaling pathway | ||||
| Insulin signaling pathway | ||||
| Panther Pathway | Triacylglycerol metabolism | |||
| Reactome | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |||
| WikiPathways | Insulin Signaling | |||
| Triacylglyceride Synthesis | ||||
| Lipid digestion, mobilization, and transport | ||||
| Adipogenesis | ||||
| Fatty Acid Beta Oxidation | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Carbazates as potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1741-4. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6702). | |||
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