Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0A9VO
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| Former ID |
DNC012301
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| Drug Name |
GYKI-52466
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| Synonyms |
Gyki-52466; 102771-26-6; GYKI 52466; UNII-471V8NZ5X3; GYKI 52466 HCl; CHEMBL275006; CHEBI:79560; 471V8NZ5X3; 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride; 4-(8-methyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline; 4-(8-Methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)benzenamine; Benzenamine,4-(8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-; Benzenamine, 4-(8-methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)-; C17H15N3O2
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Terminated | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H15N3O2
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| Canonical SMILES |
CC1=NN=C(C2=CC3=C(C=C2C1)OCO3)C4=CC=C(C=C4)N
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| InChI |
1S/C17H15N3O2/c1-10-6-12-7-15-16(22-9-21-15)8-14(12)17(20-19-10)11-2-4-13(18)5-3-11/h2-5,7-8H,6,9,18H2,1H3
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| InChIKey |
LFBZZHVSGAHQPP-UHFFFAOYSA-N
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| CAS Number |
CAS 102771-26-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7404172, 7979284, 8152239, 11111215, 11114090, 14824929, 17396037, 24277937, 29222669, 47810984, 48035358, 48259463, 49878329, 50064455, 50104854, 53789999, 57321860, 80306549, 85789031, 90341141, 99437177, 103133373, 103167505, 103978855, 104303806, 117603215, 124749873, 124757280, 124880187, 124880188, 125164084, 126407641, 126671657, 128480148, 134349506, 135062064, 142472743, 144116046, 162112768, 162221955, 162309809, 162769784, 178101027, 179149488, 198978968, 223444733, 223519189, 223653181, 224904407, 226553589
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| ChEBI ID |
CHEBI:79560
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4210). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005470) | |||
| REF 3 | New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists. Bioorg Med Chem Lett. 2006 Jan 1;16(1):167-70. | |||
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