Drug Information
Drug General Information | Top | |||
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Drug ID |
D0AJ3C
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Former ID |
DIB018090
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Drug Name |
(R)-zacopride
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Synonyms |
CHEMBL27846; UNII-38126EQF7A; 38126EQF7A; ZACOPRIDE,S; r-zacopride; (R)ZACOPRIDE; (R)-(+)-Zacopride; ZINC848; GTPL2288; SCHEMBL5387843; BDBM50031475; PDSP2_001683; PDSP1_001700; UNII-9GN3OT4156 component FEROPKNOYKURCJ-ZDUSSCGKSA-N; 4-Amino-N-(R)-1-aza-bicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxy-benzamide; 4-amino-N-[(8R)-1-azabicyclo[2.2.2]octan-8-yl]-5-chloro-2-methoxybenzamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C15H20ClN3O2
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Canonical SMILES |
COC1=CC(=C(C=C1C(=O)NC2CN3CCC2CC3)Cl)N
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InChI |
1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1
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InChIKey |
FEROPKNOYKURCJ-ZDUSSCGKSA-N
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CAS Number |
CAS 123441-85-0
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 3 receptor (5HT3R) | Target Info | Modulator | [2] |
5-HT 4 receptor (HTR4) | Target Info | Modulator | [2] | |
KEGG Pathway | Calcium signaling pathway | |||
cAMP signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
5HT4 type receptor mediated signaling pathway | ||||
Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | |||
Reactome | Serotonin receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2288). | |||
REF 2 | R-zacopride, a 5-HT3 antagonist/5-HT4 agonist, reduces sleep apneas in rats. Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):283-9. |
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