Drug Information
Drug General Information | Top | |||
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Drug ID |
D0AM8W
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Former ID |
DIB010275
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Drug Name |
Zanapezil
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Synonyms |
TAK-147
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Discontinued in Phase 3 | [1] | |
Company |
Takeda Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Formula |
C25H32N2O
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Canonical SMILES |
C1CCNC2=C(C1)C=CC(=C2)C(=O)CCC3CCN(CC3)CC4=CC=CC=C4
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InChI |
1S/C25H32N2O/c28-25(23-11-10-22-8-4-5-15-26-24(22)18-23)12-9-20-13-16-27(17-14-20)19-21-6-2-1-3-7-21/h1-3,6-7,10-11,18,20,26H,4-5,8-9,12-17,19H2
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InChIKey |
PMBLXLOXUGVTGB-UHFFFAOYSA-N
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CAS Number |
CAS 142852-50-4
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [2] |
KEGG Pathway | Glycerophospholipid metabolism | |||
Cholinergic synapse | ||||
Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
Nicotinic acetylcholine receptor signaling pathway | ||||
Pathwhiz Pathway | Phospholipid Biosynthesis | |||
Pathway Interaction Database | ATF-2 transcription factor network | |||
WikiPathways | Monoamine Transport | |||
Biogenic Amine Synthesis | ||||
Acetylcholine Synthesis | ||||
Integrated Pancreatic Cancer Pathway |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004496) | |||
REF 2 | Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats. Br J Pharmacol. 2005 Aug;145(8):1035-44. |
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