Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0AR0L
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| Drug Name |
1-phenyl-1,3,4-triazole derivative 2
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| Synonyms |
PMID28454500-Compound-77
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| Drug Type |
Small molecular drug
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| Company |
THE GENERAL HOSPITAL CORPORATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
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| Structure |
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Download2D MOL |
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| Formula |
C20H15N5O3S
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| Canonical SMILES |
C1=CC=C(C=C1)N2C(=NN=C2SC3=NC=C(C=C3)[N+](=O)[O-])COC4=CC=CC=C4
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| InChI |
1S/C20H15N5O3S/c26-25(27)16-11-12-19(21-13-16)29-20-23-22-18(14-28-17-9-5-2-6-10-17)24(20)15-7-3-1-4-8-15/h1-13H,14H2
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| InChIKey |
OZUBDKIROJPQGE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Keap1-Nrf2[DLG] PPI (KEAP1-Nrf2 DLG) | Target Info | Modulator | [1] |
| Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Keap1-Nrf2[DLG] PPI (KEAP1-Nrf2 DLG) | Target's Patent Info | [1] | |
| Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target's Patent Info | [1] | ||
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| NetPath Pathway | IL5 Signaling Pathway | |||
| WikiPathways | Oxidative Stress | |||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Mesodermal Commitment Pathway | ||||
| Aryl Hydrocarbon Receptor | ||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
| Arylhydrocarbon receptor (AhR) signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. | |||
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