Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0B1PD
|
|||
Former ID |
DIB006129
|
|||
Drug Name |
NPC-16377
|
|||
Synonyms |
Npc-16377; 139652-86-1; 6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone hydrochloride; Npc 16377; npc16377; SCHEMBL8787810; DTXSID40161144; 6-(6-(4-Hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl; 4H-1-Benzopyran-4-one, 6-((6-(4-hydroxy-1-piperidinyl)hexyl)oxy)-3-methyl-2-phenyl-, hydrochloride
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Psychotic disorder [ICD-11: 6A20-6A25] | Terminated | [1] | |
Company |
Scios Inc
|
|||
Structure |
Download2D MOL |
|||
Formula |
C27H34ClNO4
|
|||
Canonical SMILES |
CC1=C(OC2=C(C1=O)C=C(C=C2)OCCCCCCN3CCC(CC3)O)C4=CC=CC=C4.Cl
|
|||
InChI |
1S/C27H33NO4.ClH/c1-20-26(30)24-19-23(11-12-25(24)32-27(20)21-9-5-4-6-10-21)31-18-8-3-2-7-15-28-16-13-22(29)14-17-28;/h4-6,9-12,19,22,29H,2-3,7-8,13-18H2,1H3;1H
|
|||
InChIKey |
GWSBQIZSTCDSLE-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 139652-86-1
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Modulator | [2], [3], [4] |
WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
miR-targeted genes in lymphocytes - TarBase |
References | Top | |||
---|---|---|---|---|
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001997) | |||
REF 2 | Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine. J Pharmacol Exp Ther. 1993 Aug;266(2):473-82. | |||
REF 3 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. | |||
REF 4 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.