Drug Information
Drug General Information | Top | |||
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Drug ID |
D0B2NV
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Drug Name |
PMID29334795-Compound-22
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Drug Type |
Small molecular drug
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Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Patented | [1] | |
Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
Company |
LES LABORATOIRES SERVIELES LABORATOIRES SERVIER ROBERT, Nicolas LERESTIF, Jean-Michel LECOUVE, Jean-Pierre GAILLARD, Marina DELCROIX - MEUNIER, Julie LETELLIER, Philippe BOIRET, MathieLES LABORATOIRES SERVIER TROCME-THIBIERGE, Caryn SORS, Aurore KEIME GUIBERT, FlorencLES LABORATOIRES SERVIER CASARA, Patrick CHOLLET, Anne-Marie DHAINAUT, Alain BERT, Lionel LESTAGE, Pierre LOCKHART, Brian
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Structure |
Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Histamine H3 receptor (H3R) | Target Info | Agonis; Inverse agonist | [1] |
Target's Patent Info | Histamine H3 receptor (H3R) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | Monoamine Transport | |||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196. |
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