Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B5BT
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| Drug Name |
Azetidinyl-piperazine derivative 1
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| Synonyms |
PMID29053063-Compound-1
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| Drug Type |
Small molecular drug
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| Company |
JANSSEN PHARMACEUTICA NV FLORES, Christopher, M. NELEN, Marina, I. NULTON, Erica, L. PROUTY, Stephen TODD, Matthew ZHANG, Sui-PJANSSEN PHARMACEUTICA NV CHEVALIER, Kristen, M. DAX, Scott, L. FLORES, Christopher, M. LIU, Li MACIELAG, Mark, J. MCDONNELL, Mark, E. NELEN, Marina, I. PROUTY, Stephen TODD, Matthew ZHANG, Sui-Po ZHU, Bin NULTON, Erica, L. CLEMENTE, Jose
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Monoglyceride lipase (MAGL) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Monoglyceride lipase (MAGL) | Target's Patent Info | [1] | |
| BioCyc | Triacylglycerol degradation | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Metabolic pathways | ||||
| Retrograde endocannabinoid signaling | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | ||||
| WikiPathways | Lipid digestion, mobilization, and transport | |||
| Glycerophospholipid biosynthesis | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351. | |||
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