Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B8PD
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| Former ID |
DIB018672
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| Drug Name |
6-Cl-MLT
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| Synonyms |
6-Cl-melatonin; 6-chloromelatonin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C13H15ClN2O2
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| Canonical SMILES |
CC(=O)NCCC1=CNC2=CC(=C(C=C21)OC)Cl
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| InChI |
1S/C13H15ClN2O2/c1-8(17)15-4-3-9-7-16-12-6-11(14)13(18-2)5-10(9)12/h5-7,16H,3-4H2,1-2H3,(H,15,17)
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| InChIKey |
LUINDDOUWHRIPW-UHFFFAOYSA-N
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| CAS Number |
CAS 63762-74-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6755088, 8151314, 11110901, 11113504, 15491087, 17404741, 26751723, 29221055, 47291320, 47515528, 47589183, 49858543, 50104413, 50104414, 53777284, 56463294, 57321048, 75272297, 85084766, 85208929, 85230954, 85788599, 90341286, 92303628, 92474752, 103206438, 103837837, 103974758, 104298926, 117460165, 121360881, 124749516, 124800835, 124879534, 124879535, 124879536, 125666026, 128542708, 135077116, 135649846, 135698046, 137242479, 137242480, 162022438, 162092102, 163132019, 163564132, 178127342, 179235698, 184589682
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| ChEBI ID |
CHEBI:109545
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melatonin receptor type 1A (MTNR1A) | Target Info | Agonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Circadian entrainment | ||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1346). | |||
| REF 2 | Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. | |||
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