Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0B9MY
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| Former ID |
DNC003545
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| Drug Name |
8-Pyridin-4-yl-9H-purine-2,6-diamine
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| Synonyms |
CHEMBL317618; 8-Pyridin-4-yl-9H-purine-2,6-diamine; 9H-Purine-2,6-diamine, 8-(4-pyridinyl)-; AC1L9X4Y; BDBM50059928; 2,6-Diamino-8-(4'-pyridinyl)purine; 8-pyridin-4-yl-7H-purine-2,6-diamine; 8-(4-pyridyl)-9H-purine-2,6-diamine; 194613-23-5
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C10H9N7
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| Canonical SMILES |
C1=CN=CC=C1C2=NC3=NC(=NC(=C3N2)N)N
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| InChI |
1S/C10H9N7/c11-7-6-9(17-10(12)15-7)16-8(14-6)5-1-3-13-4-2-5/h1-4H,(H5,11,12,14,15,16,17)
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| InChIKey |
FRFATUHEQSVWHE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Conformationally restricted analogues of trimethoprim: 2,6-diamino-8-substituted purines as potential dihydrofolate reductase inhibitors from Pneum... J Med Chem. 1997 Sep 12;40(19):3032-9. | |||
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