Drug Information
Drug General Information | Top | |||
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Drug ID |
D0BP6R
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Drug Name |
Ethinyl-pyrazole derivative 2
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Synonyms |
PMID25435285-Compound-72
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Drug Type |
Small molecular drug
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Company |
TAISHO PHARMACEUTICAL CO., LTD. NAKAMURA Toshio SAKAGAMI Kazunari KONISHI Kazuhide YAMAMOTO Kanako MASUDA Seiji
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Structure |
Download2D MOL |
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Formula |
C20H16F3N3O3S
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Canonical SMILES |
CN1C(=C(C=N1)C#CC2=CC(=CC=C2)S(=O)(=O)N)COC3=CC=C(C=C3)C(F)(F)F
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InChI |
1S/C20H16F3N3O3S/c1-26-19(13-29-17-9-7-16(8-10-17)20(21,22)23)15(12-25-26)6-5-14-3-2-4-18(11-14)30(24,27)28/h2-4,7-12H,13H2,1H3,(H2,24,27,28)
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InChIKey |
RTQHVIORPPJRPP-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Antagonist | [1] |
Target's Patent Info | Metabotropic glutamate receptor 2 (mGluR2) | Target's Patent Info | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glutamatergic synapse | ||||
Cocaine addiction | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group II pathway | ||||
Reactome | G alpha (i) signalling events | |||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. |
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