Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0C4JX
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| Former ID |
DNC001578
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| Drug Name |
QX-314
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| Synonyms |
QX 314; CHEBI:46937; 2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxoethanaminium; 2-((2,6-Dimethylphenyl)amino)-N,N,N-triethyl-2-oxoethanaminium; Ethanaminium, 2-((2,6-dimethylphenyl)amino)-N,N,N-triethyl-2-oxo-; Tocris-1014; AC1Q5LWR; Lopac-L-5783; UPCMLD-DP014; AC1L1H0Q; SCHEMBL93854; Lopac0_000679; KBioGR_000191; BSPBio_001471; KBioSS_000191; GTPL2405; UPCMLD-DP014:001; CHEMBL1180496; C16H27N2O; KBio3_000382; KBio2_005327; KBio2_002759; KBio2_000191; KBio3_000381; QX314; Bio2_000671; Bio2_000191; ZINC2037285; CCG-204765
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| Drug Type |
Small molecular drug
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| Indication | Pain [ICD-11: MG30-MG3Z] | Terminated | [1], [2] | |
| Therapeutic Class |
Analgesics
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| Structure |
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Download2D MOL
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| Formula |
C16H27BrN2O
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| Canonical SMILES |
CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]
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| InChI |
1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
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| InChIKey |
DLHMKHREUTXMCH-UHFFFAOYSA-N
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| CAS Number |
CAS 24003-58-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4658835, 11111386, 11113855, 11121536, 11122016, 11362605, 11365167, 11367729, 11370481, 11370482, 11373330, 11375891, 22391422, 24550786, 26744343, 26752028, 26752029, 26752030, 29223039, 39674908, 46487960, 47515541, 48110680, 48110681, 50064585, 50104692, 57322054, 77373082, 85788248, 85789495, 90341298, 103112354, 104304919, 117573011, 124749913, 124880579, 124880581, 124880582, 124880583, 124880584, 125333814, 126407749, 128985284, 129803601, 135073847, 135650877, 138406848, 140712422, 179235715, 184581019
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated sodium channel alpha Nav1.9 (SCN11A) | Target Info | Blocker | [3] |
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2405). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008413) | |||
| REF 3 | Voltage-gated sodium channel blockers for the treatment of chronic pain. Curr Top Med Chem. 2009;9(4):362-76. | |||
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