Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0C7JT
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| Former ID |
DIB008134
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| Drug Name |
YM-976
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| Synonyms |
4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 1 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H16ClN3O
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| Canonical SMILES |
CCC1=NC2=C(C=C1)C(=NC(=O)N2CC)C3=CC(=CC=C3)Cl
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| InChI |
1S/C17H16ClN3O/c1-3-13-8-9-14-15(11-6-5-7-12(18)10-11)20-17(22)21(4-2)16(14)19-13/h5-10H,3-4H2,1-2H3
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| InChIKey |
MNHXYNNKDDXKNP-UHFFFAOYSA-N
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| CAS Number |
CAS 191219-80-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11114229, 11646546, 14825817, 24724671, 43224654, 50035123, 57371147, 77248208, 85789052, 90341065, 91723004, 114638231, 121360857, 124974129, 128620489, 135698467, 137032995, 140275277, 162023248, 162248250, 162808926, 163563970, 172840200, 175612235, 178101975, 184598515, 204356757, 223454724, 225076537, 226521177, 241375634, 252156125
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| ChEBI ID |
CHEBI:92225
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [3] |
| Phosphodiesterase 4B (PDE4B) | Target Info | Inhibitor | [4] | |
| Phosphodiesterase 4D (PDE4D) | Target Info | Inhibitor | [5] | |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| Myometrial Relaxation and Contraction Pathways | ||||
| TSH signaling pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Opioid Signalling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5292). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010783) | |||
| REF 3 | Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs. J Pharmacol Exp Ther. 2001 Apr;297(1):165-73. | |||
| REF 4 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | |||
| REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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