Drug Information
Drug General Information | Top | |||
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Drug ID |
D0C9TY
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Former ID |
DIB020765
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Drug Name |
PSAB-OFP
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Synonyms |
PSAB-OFP; CHEMBL195345; SCHEMBL2184386; GTPL3968; BDBM50173944; 5''-phenyl-(2''R)-spiro[4-azabicyclo[2.2.2]octane-2,2''-furo[2,3-b]pyridine]
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C19H20N2O
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Canonical SMILES |
C1CN2CCC1C3(C2)CC4=C(O3)N=CC(=C4)C5=CC=CC=C5
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InChI |
1S/C19H20N2O/c1-2-4-14(5-3-1)16-10-15-11-19(22-18(15)20-12-16)13-21-8-6-17(19)7-9-21/h1-5,10,12,17H,6-9,11,13H2/t19-/m0/s1
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InChIKey |
GIRLVGYIIVFTLI-IBGZPJMESA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Neuronal acetylcholine receptor alpha-7 (CHRNA7) | Target Info | Agonist | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Cholinergic synapse | ||||
Nicotine addiction | ||||
Chemical carcinogenesis | ||||
Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
Nicotinic acetylcholine receptor signaling pathway | ||||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3968). | |||
REF 2 | PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor. Eur J Pharmacol. 2002 Oct 4;452(2):137-44. |
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