Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0C9WD
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| Drug Name |
Thiazole-fused cycloalkyl carboxamide derivative 1
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| Synonyms |
PMID27724045-Compound-20
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| Drug Type |
Small molecular drug
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| Company |
Actelion pharmaceuticals Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H14Cl2N2O2
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| Canonical SMILES |
CC1=CC(=CC(=C1CC(=O)NC2COC3=C2C=CN=C3)Cl)Cl
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| InChI |
1S/C16H14Cl2N2O2/c1-9-4-10(17)5-13(18)12(9)6-16(21)20-14-8-22-15-7-19-3-2-11(14)15/h2-5,7,14H,6,8H2,1H3,(H,20,21)
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| InChIKey |
CPLYQTQQYXUOCX-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2X purinoceptor 7 (P2RX7) | Target Info | Antagonist | [1] |
| Target's Patent Info | P2X purinoceptor 7 (P2RX7) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Reactome | The NLRP3 inflammasome | |||
| WikiPathways | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | P2X7 receptor antagonists: a patent review (2010-2015).Expert Opin Ther Pat. 2017 Mar;27(3):257-267. | |||
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