Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0CI9W
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| Former ID |
DIB016364
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| Drug Name |
GSK-334429
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| Synonyms |
GSK-357868; GSK-678103; H3 antagonists (cognitive disorder); H3 antagonists (cognitive disorder), GlaxoSmithKline
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Investigative | [1] | |
| Company |
GlaxoSmithKline plc
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| Structure |
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Download2D MOL |
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| Formula |
C20H29F3N4O
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| Canonical SMILES |
CC(C)N1CCCN(CC1)C(=O)C2CCN(CC2)C3=CN=C(C=C3)C(F)(F)F
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| InChI |
1S/C20H29F3N4O/c1-15(2)25-8-3-9-27(13-12-25)19(28)16-6-10-26(11-7-16)17-4-5-18(24-14-17)20(21,22)23/h4-5,14-16H,3,6-13H2,1-2H3
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| InChIKey |
AHHPKVQYHXNBQN-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Antagonist | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 264). | |||
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