Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D1BR
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| Former ID |
DNCL002989
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| Drug Name |
GS-7340
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| Synonyms |
Tenofovir alafenamide; Vemlidy
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| Drug Type |
Small molecular drug
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| Indication | Hepatitis B virus infection [ICD-11: 1E51.0; ICD-10: B18.1] | Approved | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 279.3] | Phase 2 | [2] | ||
| Company |
Gilead Sciences
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| Structure |
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Download2D MOL |
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| Formula |
C21H29N6O5P
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| Canonical SMILES |
CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3
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| InChI |
1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
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| InChIKey |
LDEKQSIMHVQZJK-CAQYMETFSA-N
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| CAS Number |
CAS 379270-37-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:90926
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| ADReCS Drug ID | BADD_D02477 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2020 | |||
| REF 2 | ClinicalTrials.gov (NCT01565850) Safety and Efficacy of Darunavir/Cobicistat/Emtricitabine/GS-7340 Single Tablet Regimen Versus Cobicistat-boosted Darunavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate Fixed Dose Combination in HIV-1 Infected, Antiretroviral Treatment Naive Adults. U.S. National Institutes of Health. | |||
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