Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D2TN
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| Former ID |
DIB005104
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| Drug Name |
Rimexolone
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| Synonyms |
Rimexolone (sustained release intra-articular steroid suspension, Plexis, arthritis)
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| Drug Type |
Small molecular drug
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| Indication | Arthritis [ICD-11: FA20] | Approved | [1], [2] | |
| Company |
Auritec Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Formula |
C24H34O3
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| Canonical SMILES |
CCC(=O)C1(C(CC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C)C
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| InChI |
1S/C24H34O3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26H,6-8,11,13H2,1-5H3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1
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| InChIKey |
QTTRZHGPGKRAFB-OOKHYKNYSA-N
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| CAS Number |
CAS 49697-38-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980520, 11056486, 11467048, 11468168, 11486786, 12014133, 14804034, 14828819, 39341090, 47207390, 47871005, 47871006, 47871007, 48170707, 49699253, 50123981, 56463550, 57359468, 80240860, 85788089, 92126045, 103770600, 103914672, 114156025, 121363716, 124801082, 134224655, 135000880, 137005248, 141792894, 164233438, 164764869, 175267976, 175612108, 178103677, 179149417, 226767286, 244890192
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| ChEBI ID |
CHEBI:135566
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| ADReCS Drug ID | BADD_D01946 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Estrogen-related receptor-alpha (ESRRA) | Target Info | Modulator | [3] |
| Reactome | PPARA activates gene expression | |||
| Transcriptional activation of mitochondrial biogenesis | ||||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Mitochondrial Gene Expression | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7099). | |||
| REF 2 | ClinicalTrials.gov (NCT00471419) Phase II Study of AL-2178 (FID 109980) in the Treatment of Dry Eye. U.S. National Institutes of Health. | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 622). | |||
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