Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D4UH
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| Drug Name |
PMID28394193-Compound-46
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| Drug Type |
Small molecular drug
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| Company |
PFIZER INC
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H21Cl2N3O4
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| Canonical SMILES |
CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)C4=C(ON=C4CO)C)Cl)C
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| InChI |
1S/C22H21Cl2N3O4/c1-10-6-11(2)25-21(29)15(10)8-27-5-4-13-16(23)7-14(20(24)19(13)22(27)30)18-12(3)31-26-17(18)9-28/h6-7,28H,4-5,8-9H2,1-3H3,(H,25,29)
|
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| InChIKey |
WZHICSHLNWIANY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Enhancer of zeste homolog 2 (EZH2) | Target Info | Inhibitor | [1] |
| EZH2 Y641N mutant (EZH2 Y641N) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Enhancer of zeste homolog 2 (EZH2) | Target's Patent Info | [1] | |
| EZH2 Y641N mutant (EZH2 Y641N) | Target's Patent Info | [1] | ||
| KEGG Pathway | MicroRNAs in cancer | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Reactome | PRC2 methylates histones and DNA | |||
| Oxidative Stress Induced Senescence | ||||
| PKMTs methylate histone lysines | ||||
| WikiPathways | Interactome of polycomb repressive complex 2 (PRC2) | |||
| Endoderm Differentiation | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| Histone Modifications | ||||
| Cell Differentiation - meta | ||||
| miRs in Muscle Cell Differentiation | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813. | |||
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