Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D5ZJ
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Former ID |
DNCL003511
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Drug Name |
Momelotinib
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Synonyms |
Cyt387; 1056634-68-4; MOMELOTINIB; Cyt-387; N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide; CYT 387; CYT 11387; UNII-6O01GMS00P; N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide; 6O01GMS00P; CHEMBL1078178; AK102858; N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide; N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide; CYT387 sulfate salt; N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide
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Drug Type |
Small molecular drug
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Indication | Myelofibrosis [ICD-11: 2A20.2; ICD-10: D47.4] | Approved | [1] | |
Polycythemia vera [ICD-11: 2A20.4; ICD-10: D45; ICD-9: 238.4] | Phase 2 | [2] | ||
Thrombocythemia [ICD-11: 3B63; ICD-9: 289.9] | Phase 2 | [2] | ||
Company |
GSK
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Structure |
Download2D MOL |
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Formula |
C23H22N6O2
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Canonical SMILES |
C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
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InChI |
1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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InChIKey |
ZVHNDZWQTBEVRY-UHFFFAOYSA-N
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CAS Number |
CAS 1056634-68-4
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PubChem Compound ID | ||||
PubChem Substance ID |
56399705, 57547838, 103743167, 104145378, 124360692, 124757657, 125164461, 125329924, 126626053, 135264539, 135685340, 135685341, 135685358, 136340258, 136349480, 136367611, 136920393, 137275866, 141008222, 144115871, 152044043, 152258277, 152344050, 160647116, 160832829, 162011551, 162037827, 162108949, 162202685, 163095742, 163312345, 163397224, 163908034, 164045353, 164194015, 170497647, 172918915, 174561051, 177749171, 180386993, 186014831, 198982471, 204365729, 223366122, 223377998, 223617445, 223653818, 223705187, 228364131, 242060323
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ChEBI ID |
CHEBI:91407
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References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 216873 | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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