Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D7MJ
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| Former ID |
DIB005168
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| Drug Name |
CNSB-001
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| Synonyms |
Flupirtine + opioid (fixed dose, diabetic neuropathic pain), CNSBio; Flupirtine + opioid (fixed dose, diabetic neuropathic pain), Relevare
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| Indication | Neuropathic pain [ICD-11: 8E43.0] | Phase 2 | [1] | |
| Company |
Relevare Pharmaceuticals Ltd
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor (OPR) | Target Info | Agonist | [2] |
| Voltage-gated potassium channel Kv7 (KCNQ) | Target Info | Agonist | [3] | |
| KEGG Pathway | Adrenergic signaling in cardiomyocytes | |||
| Cholinergic synapse | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Protein digestion and absorption | ||||
| Vibrio cholerae infection | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029018) | |||
| REF 2 | Molecular Mechanisms of Opioid Receptor-Dependent Signaling and Behavior. Anesthesiology. 2011 December; 115(6): 1363-1381. | |||
| REF 3 | The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve. J Peripher Nerv Syst. 2010 Mar;15(1):63-72. | |||
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