Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D7YW
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| Drug Name |
TC-5214
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| Synonyms |
Dexmecamylamine; DEXMECAMYLAMINE; UNII-5Y1141YI4U; 107538-05-6; 5Y1141YI4U; TC 5214; (1R,2S,4S)-N,2,3,3-Tetramethylbicyclo(2.2.1)heptan-2-amine; Dexmecamylamine [USAN:INN]; Dexmecamylamine (USAN); CHEMBL2103881; BDBM50045047; ZINC43763856; DB11807; D10111; UNII-6EE945D3OK component IMYZQPCYWPFTAG-NGZCFLSTSA-N; Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-, (1R,2S,4S)-
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| Indication | Palmar hyperhidrosis [ICD-11: EE00.00] | Phase 2 | [1] | |
| Company |
Atacama Therapeutics Wellesley, MA
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| Structure |
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Download2D MOL
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| Formula |
C11H22ClN
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| Canonical SMILES |
CC1(C2CCC(C2)C1(C)NC)C.Cl
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| InChI |
1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11-;/m0./s1
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| InChIKey |
PKVZBNCYEICAQP-GSTSRXQZSA-N
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| CAS Number |
CAS 107596-30-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-3/beta-4 (CHRNA3/B4) | Target Info | Antagonist | [1] |
| Neuronal acetylcholine receptor beta-2 (CHRNB2) | Target Info | Antagonist | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Cholinergic synapse | ||||
| Nicotine addiction | ||||
| Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
| Nicotine pharmacodynamics pathway | ||||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| Highly calcium permeable nicotinic acetylcholine receptors | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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