Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D8MG
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| Former ID |
DIB001723
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| Drug Name |
NOX-A12
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| Synonyms |
Ocular antineovascularisation agent/angiogenesis inhibitor (diabetic retinopathy/AMD), NOXXON; SDF-1 inhbitor (spiegelmer, stem cell transplantation), NOXXON; CXCL12 inhibitor (spiegelmer, diabetic retinopathy/AMD/stem cell transplantation), Noxxon
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| Indication | Macular degeneration [ICD-11: 9B78.3; ICD-10: H35.3; ICD-9: 362.5] | Phase 1 | [1] | |
| Company |
NOXXON Pharma AG
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Stromal cell-derived factor 1 (CXCL12) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Chemokine signaling pathway | ||||
| NF-kappa B signaling pathway | ||||
| Axon guidance | ||||
| Leukocyte transendothelial migration | ||||
| Intestinal immune network for IgA production | ||||
| Pathways in cancer | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL-7 Signaling Pathway | |||
| TWEAK Signaling Pathway | ||||
| Panther Pathway | Axon guidance mediated by Slit/Robo | |||
| Pathway Interaction Database | CXCR4-mediated signaling events | |||
| Syndecan-4-mediated signaling events | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Nuclear signaling by ERBB4 | |||
| Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | EV release from cardiac cells and their functional effects | |||
| Signaling by ERBB4 | ||||
| Allograft Rejection | ||||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01194934) NOX-A12 Multiple Ascending Dose Study in Healthy Volunteers. U.S. National Institutes of Health. | |||
| REF 2 | SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015 Dec;28(12):1426-35. | |||
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