Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0DF1R
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| Former ID |
DNC001488
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| Drug Name |
Ulinastatin
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| Synonyms |
Urinastatin; Urinary trypsin inhibitor; Trypsin inhibitor MR-20; MR-20 (Magnetic powder); Uti(68); Acid-stable protease inhibitor; Urinary trypsin inhibitor (68); 2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-; 80449-31-6; Urinary trypsin inhibitor-like inhibitor (43); Trypsin inhibitor (human urine urinastatin protein moiety); 80449-32-7; 2,4-Dioxaspiro(5.5)undec-8-ene, 3-(2-furanyl)-; Miraclid; AC1L2Y1N; UTI68; 3-(2-Furanyl)-2,4-dioxaspiro(5.5)undec-8-ene; AC1Q70L4; AKOS025401879; CS-7119; MR 20 (magnetic p
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| Drug Type |
Small molecular drug
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| Indication | Premature labour [ICD-11: JB00; ICD-10: O60] | Phase 3 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H16O3
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| Canonical SMILES |
C1CC2(CC=C1)COC(OC2)C3=CC=CO3
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| InChI |
1S/C13H16O3/c1-2-6-13(7-3-1)9-15-12(16-10-13)11-5-4-8-14-11/h1-2,4-5,8,12H,3,6-7,9-10H2
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| InChIKey |
ODVKSTFPQDVPJZ-UHFFFAOYSA-N
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| CAS Number |
CAS 80449-32-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cationic trypsinogen (PRSS1) | Target Info | Modulator | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Pancreatic secretion | ||||
| Protein digestion and absorption | ||||
| Influenza A | ||||
| Reactome | Activation of Matrix Metalloproteinases | |||
| Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
| WikiPathways | Activation of Matrix Metalloproteinases | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study. Intensive Care Med. 2014 Jun;40(6):830-8. | |||
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