Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0DI3E
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| Former ID |
DIB014299
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| Drug Name |
DHP-218
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| Synonyms |
Dhp-218; 102097-78-9; Dhp 218; 3-Pyridinecarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxido-1,3,2-dioxaphosphorinan-2-yl)-,methyl ester; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxido-1,3,2-dioxaphosphorinan-2-yl)-, methyl ester;3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxido-1,3,2-dioxaphosphorinan-2-yl)-, methyl ester; AC1O3SAA; ACMC-20m53m; SCHEMBL1356340; CTK4A0679; AKOS030566270; Methyl 2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxo-1,
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
| Company |
Nippon Shinyaku Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C18H21N2O7P
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| Canonical SMILES |
CC1=C(C(C(=C(N1)C)P2(=O)OCCCO2)C3=CC=CC=C3[N+](=O)[O-])C(=O)OC
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| InChI |
1S/C18H21N2O7P/c1-11-15(18(21)25-3)16(13-7-4-5-8-14(13)20(22)23)17(12(2)19-11)28(24)26-9-6-10-27-28/h4-5,7-8,16,19H,6,9-10H2,1-3H3
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| InChIKey |
GSWINTXYUFHJGW-UHFFFAOYSA-N
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| CAS Number |
CAS 102097-78-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Modulator | [2] |
| References | Top | |||
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| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000422) | |||
| REF 2 | Effect of DHP-218, a novel dihydropyridine phosphonate, on atrioventricular nodal conductivity compared with its vascular effect in dogs. J Cardiovasc Pharmacol. 1987 Sep;10(3):274-9. | |||
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