Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E4WR
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| Former ID |
DAP000889
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| Drug Name |
Azelaic Acid
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| Synonyms |
AZA; Azelaic; Azelex; Finacea; Finevin; Skinorem; Skinoren; Acide azelaique; Acide azelaique [French]; Acido azelaico; Acido azelaico [Spanish]; Acidum azelaicum; Acidum azelaicum [Latin]; Anchoic acid; Azalaic Acid; Azelaic acid polyanhydride; Azelaic polyanhydride; Azelainic acid; Azleaic Acid; Heptanedicarboxylic acid; Lepargylic acid; NONANEDIOIC ACID; Nonanedioic acid; Polyazelaic anhydride; AZ1; Dicarboxylic acid C9; Emerox 1110; Emerox 1144; ZK 62498; A-9800; AGN-191861; Azelaic acid [USAN:INN]; Azelaic acid,technical grade; Azelex (TN); Finacea (TN); Finevin (TN); N-Nonanedioic acid; Nonanedioic acid, homopolymer; Poly(azelaic anhydride); SH-441; Skinoren (TN); ZK-62498; AZELAIC ACID, 95%; Azelaic acid (USAN/INN); Emery's L-110; 1,7-Heptanedicarboxylic acid; 1,9-Nonanedioic acid
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| Drug Type |
Small molecular drug
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| Indication | Acne vulgaris [ICD-11: ED80; ICD-10: L70.0; ICD-9: 706.1] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Dermatologic Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H16O4
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| Canonical SMILES |
C(CCCC(=O)O)CCCC(=O)O
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| InChI |
1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)
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| InChIKey |
BDJRBEYXGGNYIS-UHFFFAOYSA-N
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| CAS Number |
CAS 123-99-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10460, 82388, 598328, 833095, 3132046, 4503339, 7886019, 8139926, 8149608, 8151524, 10506000, 11110663, 11335707, 11360946, 11362851, 11365413, 11367975, 11371356, 11373801, 11376137, 11461918, 11484825, 11488811, 11490094, 11492216, 11493871, 11528613, 11537636, 12013195, 14710853, 15195285, 17397189, 17404615, 24278221, 24869448, 24891477, 26612002, 26679444, 26747429, 26747430, 26747431, 26753510, 29221439, 46393271, 46506284, 46530506, 47515289, 47885374, 48035077, 48334457
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| ChEBI ID |
CHEBI:48131
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| ADReCS Drug ID | BADD_D00197 | |||
| SuperDrug ATC ID |
D10AX03
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| SuperDrug CAS ID |
cas=000123999
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) | Target Info | Inhibitor | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7484). | |||
| REF 2 | Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs. 1991 May;41(5):780-98. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol. 1988 Nov;119(5):627-32. | |||
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