Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0E6OC
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| Former ID |
DAP001531
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| Drug Name |
Tranilast
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| Synonyms |
tranilast; 53902-12-8; Rizaben; trans-Tranilast; Tranilastum; 70806-55-2; MK 341; N-(3,4-Dimethoxycinnamoyl)anthranilic acid; Tranilastum [INN-Latin]; Tranilast [USAN:INN:JAN]; Tranpro; UNII-HVF50SMY6E; SB-252218; MK-341; Tranilast (SB 252218); 3,4-DAA; n-(3',4'-dimethoxycinnamoyl) anthranilic acid; HVF50SMY6E; MLS000028468; CHEBI:77572; C18H17NO5; Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-; NZHGWWWHIYHZNX-CSKARUKUSA-N; 2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid; MFCD00864787; T 0318; NU-3450; Rizaben (TN); Tranilast (JAN/USAN/INN); Rizaben, SB 252218, MK 341, Tranpro ,Tranilast; N-(3',4'-dimethoxycinnamoyl) anthranilic acid; N-(3′ -Dimethoxycinnamoyl)anthranilic Acid; 2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid; 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid; Molecule 20
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| Drug Type |
Small molecular drug
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| Indication | Ocular allergy [ICD-11: 4A81] | Approved | [1], [2] | |
| Company |
Kissei
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| Structure |
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Download2D MOL |
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| Formula |
C18H17NO5
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| Canonical SMILES |
COC1=C(C=C(C=C1)C=CC(=O)NC2=CC=CC=C2C(=O)O)OC
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| InChI |
1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
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| InChIKey |
NZHGWWWHIYHZNX-CSKARUKUSA-N
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| CAS Number |
CAS 53902-12-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855567, 7849089, 8616956, 12013287, 14801725, 17405845, 24278719, 26612911, 26680238, 26719641, 26759646, 39315705, 46386750, 47589114, 47810891, 47885539, 48416652, 49645767, 49684379, 49700724, 49887093, 50103918, 50103919, 50103920, 53778299, 56422140, 57288861, 57358583, 75624513, 85231347, 85789432, 87870631, 89850281, 90341124, 92303237, 92308202, 92308335, 92308903, 92711430, 99437152, 99444086, 103330746, 107388281, 113856723, 118303066, 121362071, 124637814, 124757248, 124799410, 124883425
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| ChEBI ID |
CHEBI:77572
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides fragilis HMW 610
Show/Hide Hierarchy
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[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tranilast can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.56; p = 0.033). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 3731
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Tranilast can be metabolized by Bacteroides thetaiotaomicron 3731 (log2FC = -0.45; p = 0.023). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [2] |
| Steryl-sulfatase (STS) | Target Info | Inhibitor | [4] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Steroid hormone biosynthesis | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| Glycosphingolipid metabolism | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| Estrogen metabolism | ||||
| Vitamin D Receptor Pathway | ||||
| Sphingolipid metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6326). | |||
| REF 2 | Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Review of estrone sulfatase and its inhibitors--an important new target against hormone dependent breast cancer. Curr Med Chem. 2002 Jan;9(2):263-73. | |||
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