Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0EC6Q
|
|||
Former ID |
DAP001080
|
|||
Drug Name |
Chlophedianol
|
|||
Synonyms |
Abehol; Antitussin; Calmotusin; Chlofedanol; Clofedano; Clofedanol; Clofedanolum; Clofedianolo; Dencyl; Eutus; Tussistop; Clofedianolo [Italian]; Clophedianol base; Ulo base; SL 501 base; Antitussin (TN); Clofedanol (INN); Clofedanol [INN:BAN]; Clofedanolum [INN-Latin]; Ulone (TN); Alpha-(Dimethylaminoethyl)-o-chlorobenzhydrol; Benzenemethanol, 2-chloro-alpha-(2-(dimethylamino)ethyl)-alpha-phenyl-(9CI); 1-(2-Chlorophenyl)-1-phenyl-3-dimethylaminopropanol; 1-(2-Chlorophenyl)-3-(dimethylamino)-1-phenyl-1-propanol; 1-(2-chlorophenyl)-3-(dimethylamino)-1-phenylpropan-1-ol; 1-(2-chlorophenyl)-3-dimethylamino-1-phenylpropan-1-ol; 1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol; 2-Chloro-.alpha.-(2-dimethylaminoethyl)benzhydrol; 2-Chloro-alpha-(2-(dimethylamino)ethyl)benzhydrol; 2-Cloro-alpha-(2-dimetilaminoetil)-benzidrolo; 2-Cloro-alpha-(2-dimetilaminoetil)-benzidrolo [Italian]
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Indication | Dry cough [ICD-11: MD12; ICD-10: R05] | Approved | [1] | |
Anaesthesia [ICD-11: 9A78.6; ICD-9: 338] | Withdrawn from market | [2], [3] | ||
Therapeutic Class |
Anesthetics
|
|||
Company |
3m Pharmaceuticals Inc
|
|||
Structure |
Download2D MOL |
|||
Formula |
C17H20ClNO
|
|||
Canonical SMILES |
CN(C)CCC(C1=CC=CC=C1)(C2=CC=CC=C2Cl)O
|
|||
InChI |
1S/C17H20ClNO/c1-19(2)13-12-17(20,14-8-4-3-5-9-14)15-10-6-7-11-16(15)18/h3-11,20H,12-13H2,1-2H3
|
|||
InChIKey |
WRCHFMBCVFFYEQ-UHFFFAOYSA-N
|
|||
CAS Number |
CAS 791-35-5
|
|||
PubChem Compound ID | ||||
PubChem Substance ID |
410735, 4302580, 7978913, 8151804, 10536090, 15072214, 29221950, 46505324, 48415749, 49882256, 51092017, 57321464, 79517463, 92714644, 93577132, 104301634, 117474833, 126407447, 126629469, 129621965, 134338337, 134445563, 134976272, 137267236, 144206265, 152101662, 160967813, 178103896, 179225595, 223671904, 226416735, 241134347, 249924746
|
|||
ChEBI ID |
CHEBI:135207
|
|||
SuperDrug ATC ID |
R05DB10
|
|||
SuperDrug CAS ID |
cas=000791355
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [4] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Inflammatory mediator regulation of TRP channels | ||||
Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
Reactome | Histamine receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Monoamine GPCRs | |||
GPCRs, Class A Rhodopsin-like | ||||
IL-4 Signaling Pathway | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7324). | |||
REF 3 | Drug information of Chlophedianol, 2008. eduDrugs. | |||
REF 4 | Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry. J Chromatogr. 1988 Aug 19;430(1):31-41. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.