Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0EP5O
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| Former ID |
DIB013874
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| Drug Name |
NS-377
|
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Terminated | [1] | |
| Company |
NeuroSearch A/S
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H16N2O2
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| Canonical SMILES |
CCN1CC2=C(C1)C3=C(C=C2C4=CC=CC=C4)C(=O)C(=O)N3
|
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| InChI |
1S/C18H16N2O2/c1-2-20-9-14-12(11-6-4-3-5-7-11)8-13-16(15(14)10-20)19-18(22)17(13)21/h3-8H,2,9-10H2,1H3,(H,19,21,22)
|
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| InChIKey |
IWRZGAAKMZJBHL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA (GRIA) | Target Info | Antagonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005356) | |||
| REF 2 | In vivo and in vitro evaluation of AMPA receptor antagonists in rat hippocampal neurones and cultured mouse cortical neurones. Eur J Pharmacol. 1998 Jul 24;353(2-3):159-67. | |||
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