Drug Information
Drug General Information | Top | |||
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Drug ID |
D0EQ3O
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Drug Name |
Pyrazolo[1,5-a]pyrimidine derivative 4
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Synonyms |
PMID26161824-Compound-134
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Drug Type |
Small molecular drug
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Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
Company |
Mitsubishi Tanabe Pharma Corporation MORITANI, Yasunori SHIRAI, Kimihiro OI, Marik
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Structure |
Download2D MOL |
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Formula |
C26H17Cl2F3N6O
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Canonical SMILES |
CN(C1=CC=CC=N1)NC(=O)C2=C3N=CC(=C(N3N=C2C(F)(F)F)C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl
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InChI |
1S/C26H17Cl2F3N6O/c1-36(20-8-4-5-13-32-20)35-25(38)21-23(26(29,30)31)34-37-22(15-9-11-16(27)12-10-15)18(14-33-24(21)37)17-6-2-3-7-19(17)28/h2-14H,1H3,(H,35,38)
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InChIKey |
BOANGAFVCNVTRF-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
KEGG Pathway | Rap1 signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | ||||
Panther Pathway | Endogenous cannabinoid signaling | |||
Pathway Interaction Database | N-cadherin signaling events | |||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Small Ligand GPCRs | ||||
BDNF signaling pathway | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. |
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