Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0EQ9T
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| Former ID |
DIB012073
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| Drug Name |
JNJ-39220675
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| Synonyms |
Histamine H3 receptor antagonist (allergic rhinitis/alcoholism), Johnson & Johnson
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| Drug Type |
Small molecular drug
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| Indication | Alcohol dependence [ICD-11: 6C40.2; ICD-10: F10.2; ICD-9: 303] | Phase 2 | [1] | |
| Company |
Johnson & Johnson Pharmaceutical Research & Development LLC
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| Structure |
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Download2D MOL |
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| Formula |
C21H24FN3O2
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| Canonical SMILES |
C1CC(C1)N2CCCN(CC2)C(=O)C3=CN=C(C=C3)OC4=CC=C(C=C4)F
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| InChI |
1S/C21H24FN3O2/c22-17-6-8-19(9-7-17)27-20-10-5-16(15-23-20)21(26)25-12-2-11-24(13-14-25)18-3-1-4-18/h5-10,15,18H,1-4,11-14H2
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| InChIKey |
IQOWHZHNGJXGHG-UHFFFAOYSA-N
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| CAS Number |
CAS 959740-39-7
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00804687) An Efficacy Study of JNJ-39220675 and Pseudoephedrine in Participants With Allergic Rhinitis. U.S. National Institutes of Health. | |||
| REF 2 | JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41. | |||
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