Drug Information
Drug General Information | Top | |||
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Drug ID |
D0EY0A
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Former ID |
DCL001155
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Drug Name |
AZD7687
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Synonyms |
AZD7687; 1166827-44-6; CHEMBL2178944; CHEMBL2178953; AZD-7687; AZD 7687; UNII-6QTJ9P2NYT; 6QTJ9P2NYT; SCHEMBL2252415; SCHEMBL5532381; SCHEMBL2252417; GTPL7827; SCHEMBL2255196; DTXSID60655297; YXFNPRHZMOGREC-SHTZXODSSA-N; 3466AH; ZINC43206395; BDBM50399684; BDBM50399710; AZD 7687;AZD-7687; ZINC101581684; AKOS030526281; CS-1026; NCGC00378858-01; HY-15497; KB-144428; W-5990; {4-[4-(6-Carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid; {trans-4-[4-(6-carbamoyl-3,5-dimethylpyrazin-2-yl)phenyl]cyclohexyl}acetic acid
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Drug Type |
Small molecular drug
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Indication | Diabetic complication [ICD-11: 5A2Y] | Phase 1 | [1], [2] | |
Obesity [ICD-11: 5B81; ICD-10: E66] | Phase 1 | [1], [2] | ||
Company |
AstraZeneca
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Structure |
Download2D MOL
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Formula |
C21H25N3O3
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Canonical SMILES |
CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O
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InChI |
1S/C21H25N3O3/c1-12-19(24-20(21(22)27)13(2)23-12)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(25)26/h7-10,14-15H,3-6,11H2,1-2H3,(H2,22,27)(H,25,26)
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InChIKey |
YXFNPRHZMOGREC-UHFFFAOYSA-N
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CAS Number |
CAS 1166827-44-6
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [2] |
BioCyc | Triacylglycerol biosynthesis | |||
KEGG Pathway | Glycerolipid metabolism | |||
Retinol metabolism | ||||
Metabolic pathways | ||||
Fat digestion and absorption | ||||
Pathwhiz Pathway | Retinol Metabolism | |||
Reactome | Acyl chain remodeling of DAG and TAG | |||
Triglyceride Biosynthesis | ||||
WikiPathways | Vitamin A and Carotenoid Metabolism | |||
Statin Pathway | ||||
Triacylglyceride Synthesis | ||||
Glycerophospholipid biosynthesis | ||||
Fatty acid, triacylglycerol, and ketone body metabolism |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7827). | |||
REF 2 | Clinical pipeline report, company report or official report of AstraZeneca (2011). |
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