Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F1UL
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| Former ID |
DAP001205
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| Drug Name |
Dydrogesterone
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| Synonyms |
Dehydrogesterone; Didrogesterona; Didrogesterone; Diphaston; Dufaston; Duphaston; Duvaron; Dydrogesterona; Dydrogesteronum; Gestatron; Gynorest; Hydrogesterone; Hydrogestrone; Isopregnenone; Prodel; Retrone; Terolut; Didrogesterone [DCIT]; Solvay Brand of Dydrogesterone; DELTA6-Retroprogesterone; Duphaston (TN); Dydrogesterona [INN-Spanish]; Dydrogesteronum [INN-Latin]; Gynorest (TN); Delta(6)-Retroprogesterone; Delta(sup 6)-Retroprogesterone; Retro-6-dehydroprogesterone; Dydrogesterone (JP15/USP/INN); Dydrogesterone [USAN:INN:BAN:JAN]; Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)-(9CI); (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one; (9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione; (9beta,10alpha)-pregna-4,6-diene-3,20-dione; 10alpha-Isopregnenone; 6 Dehydro 9 beta 10 alpha progesterone; 6-Dehydro-9 beta-10 alpha-progesterone; 6-Dehydro-9.beta.,10.alpha.-progesterone; 6-Dehydro-9beta,10alpha-progesterone; 6-Dehydro-retro-progesterone; 6-Dehydroretroprogesterone; 9-.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9-beta,10-alpha-Pregna-4,6-diene-3,20-dione; 9-beta,10alpha-Pregna-4,6-diene-3,20-dione; 9.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI)
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| Drug Type |
Small molecular drug
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| Indication | Menstrual disorder [ICD-11: GA20.3; ICD-10: N92.5, N92.6; ICD-9: 626] | Approved | [1], [2] | |
| Therapeutic Class |
Progesterones
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| Company |
Solvay Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H28O2
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| Canonical SMILES |
CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C
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| InChI |
1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1
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| InChIKey |
JGMOKGBVKVMRFX-HQZYFCCVSA-N
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| CAS Number |
CAS 152-62-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
398384, 7848280, 7979141, 8156439, 11466699, 11467819, 11486418, 14898944, 15444771, 29227669, 46506195, 47365375, 47736654, 47736655, 48259427, 48415933, 49699132, 50019401, 50124160, 50751954, 53787025, 56394852, 56463092, 57325399, 71822875, 85788500, 87325136, 92125727, 103770836, 103914481, 104319423, 121363398, 124799336, 126653040, 126667084, 128271591, 134338445, 134973758, 135650214, 137005553, 139642162, 144203980, 152034951, 160963725, 162177763, 164178107, 170465104, 175611963, 179149345, 184546093
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| ChEBI ID |
CHEBI:31527
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| SuperDrug ATC ID |
G03DB01
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| SuperDrug CAS ID |
cas=000152625
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Progesterone receptor (PGR) | Target Info | Agonist | [3] |
| KEGG Pathway | Oocyte meiosis | |||
| Progesterone-mediated oocyte maturation | ||||
| Pathway Interaction Database | Cellular roles of Anthrax toxin | |||
| Reactome | Nuclear signaling by ERBB4 | |||
| Nuclear Receptor transcription pathway | ||||
| WikiPathways | Ovarian Infertility Genes | |||
| Signaling by ERBB4 | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2878). | |||
| REF 2 | Drug information of Dydrogesterone, 2008. eduDrugs. | |||
| REF 3 | Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharm... Steroids. 2008 Feb;73(2):222-31. | |||
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