Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0F1UZ
|
|||
| Former ID |
DCL000696
|
|||
| Drug Name |
Amitriptyline+ketamine
|
|||
| Synonyms |
AmiKet
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Neuropathic pain [ICD-11: 8E43.0] | Phase 3 | [1] | |
| Diabetic neuropathy [ICD-11: 8C0Z] | Phase 2 | [2] | ||
| Postherpetic neuralgia [ICD-11: 1E91.5; ICD-10: G53.0; ICD-9: 53.19] | Phase 2 | [3] | ||
| Therapeutic Class |
Analgesics
|
|||
| Company |
EpiCept Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H17ClN4O2S
|
|||
| Canonical SMILES |
CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4.Cl
|
|||
| InChI |
1S/C20H16N4O2S.ClH/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18;/h3-12H,1-2H3;1H
|
|||
| InChIKey |
HPYLZBPCIBFRAI-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Antagonist | [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A Phase III Randomized, Placebo-Controlled Study of Topical Amitriptyline and Ketamine for Chemotherapy-Induced Peripheral Neuropathy (CIPN): A University of Rochester CCOP Study of 462 Cancer Survivors. Support Care Cancer. 2014 July; 22(7): 1807-1814. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 4 | Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.