Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F3SY
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| Former ID |
DIB003545
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| Drug Name |
Tegafur
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| Synonyms |
Tegafur (Fluoropyrimidine)
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H9FN2O3
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| Canonical SMILES |
C1CC(OC1)N2C=C(C(=O)NC2=O)F
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| InChI |
1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
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| InChIKey |
WFWLQNSHRPWKFK-UHFFFAOYSA-N
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| CAS Number |
CAS 17902-23-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:32188
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli Nissle 1917
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[2] | |||
| Hierarchy | ||||
| Metabolic Effect | Increase activity | |||
| Description | Tegafur can be metabolized by Escherichia coli Nissle 1917, which results in the increase of the drug's activity. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep. 2015 Sep 29;5:14554. | |||
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