Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F4FK
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| Former ID |
DIB020128
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| Drug Name |
KB-R7943
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| Synonyms |
182004-65-5; KB-R7943 mesylate; KB-R7943; 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE; KB-R7943 (mesylate); 4-((4-Nitrobenzyl)oxy)phenethyl carbamimidothioate methanesulfonate; 4-((4-Nitrobenzyl)oxy)phenethyl carbamimidothioatemethanesulfonate; 2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate; 4-[(4-Nitrobenzyl)oxy]phenethyl Carbamimidothioate Methanesulfonate; KB-R7943 mesylate; SCHEMBL742683; GTPL4232; CTK0H1228; DTXSID50431360; MolPort-003-983-603; C16H17N3O3S.CH4O3S; HMS3267H09
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C17H21N3O6S2
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| Canonical SMILES |
CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
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| InChI |
1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
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| InChIKey |
WGIKEBHIKKWJLG-UHFFFAOYSA-N
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| CAS Number |
CAS 182004-65-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
14782932, 24126784, 26759016, 44859801, 53787240, 53800721, 57373438, 79464357, 91746340, 135698241, 152079652, 152258706, 152344476, 160647542, 160821209, 162022899, 162249106, 163300006, 163374669, 163687832, 172844987, 175612701, 178101049, 184559922, 186014463, 204398567, 206251943, 208264937, 223393652, 227029080, 241182266, 242060122, 252215637, 252316128, 252433933, 252553669
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Short transient receptor potential channel 3 (TRPC3) | Target Info | Blocker (channel blocker) | [2] |
| Short transient receptor potential channel 5 (TRPC5) | Target Info | Blocker (channel blocker) | [3] | |
| Short transient receptor potential channel 6 (TRPC6) | Target Info | Blocker (channel blocker) | [4] | |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Endothelins | |||
| Nephrin/Neph1 signaling in the kidney podocyte | ||||
| EPO signaling pathway | ||||
| PAR1-mediated thrombin signaling events | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | Effects of PIP2 hydrolysis | |||
| TRP channels | ||||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Platelet homeostasis | ||||
| Netrin-1 signaling | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4232). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 488). | |||
| REF 3 | The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun. 2007 Sep 14;361(1):230-6. | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 491). | |||
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