Drug Information
Drug General Information | Top | |||
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Drug ID |
D0F4MI
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Former ID |
DIB013836
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Drug Name |
TAK-075
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Synonyms |
Calcium-sensing receptor antagonists (osteoporosis), Takeda
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Drug Type |
Small molecular drug
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Indication | Osteoporosis [ICD-11: FB83.0; ICD-10: M85.8] | Investigative | [1] | |
Company |
Takeda Pharmaceutical Co Ltd
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Structure |
Download2D MOL
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Formula |
C36H46N4O4S
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Canonical SMILES |
CCC1=CC=C(C=C1)C(CC)(CC)NC(=O)C2=C3NC(CC(N3N=C2C)(C)C)C4=CC=CC=C4.CC1=CC=C(C=C1)S(=O)(=O)O
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InChI |
1S/C29H38N4O.C7H8O3S/c1-7-21-15-17-23(18-16-21)29(8-2,9-3)31-27(34)25-20(4)32-33-26(25)30-24(19-28(33,5)6)22-13-11-10-12-14-22;1-6-2-4-7(5-3-6)11(8,9)10/h10-18,24,30H,7-9,19H2,1-6H3,(H,31,34);2-5H,1H3,(H,8,9,10)/t24-;/m1./s1
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InChIKey |
NDWLAPXXXCPRNP-GJFSDDNBSA-N
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CAS Number |
CAS 667931-33-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Extracellular calcium-sensing receptor (CASR) | Target Info | Antagonist | [1] |
Pathway Interaction Database | E-cadherin signaling in keratinocytes | |||
Reactome | G alpha (q) signalling events | |||
G alpha (i) signalling events | ||||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 54). |
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