Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F6GR
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| Former ID |
DNC000446
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| Drug Name |
Clentiazem
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| Synonyms |
CLENTIAZEM; Clentiazem [INN]; Clentiazemum [INN-Latin]; UNII-40DK034DRC; 40DK034DRC; 96125-53-0; C22H25ClN2O4S; (+)-cis-2-(4-Methoxyphenyl)-3-acetoxy-5-(2-(N,N-dimethylamino)ethyl)-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one; Clentiazemum; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (25-cis)-; 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-8-chloro-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-; AC1L1M5S; SCHEMBL33909
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Terminated | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C22H25ClN2O4S
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| Canonical SMILES |
CC(=O)OC1C(SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
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| InChI |
1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
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| InChIKey |
GYKFWCDBQAFCLJ-RTWAWAEBSA-N
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| CAS Number |
CAS 96125-53-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Modulator | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000188) | |||
| REF 2 | Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure. Cardiovasc Drugs Ther. 1997 Mar;11(1):71-9. | |||
| REF 3 | Immunosuppressive properties of the benzothiazepine calcium antagonists diltiazem and clentiazem, with and without cyclosporine, in heterotopic rat... Transplantation. 1993 Jul;56(1):181-4. | |||
| REF 4 | The effect of a new calcium antagonist, TA3090 (clentiazem), on experimental transient focal cerebral ischemia in cats. Stroke. 1993 Jun;24(6):872-8; discussion 879. | |||
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