Drug Information
Drug General Information | Top | |||
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Drug ID |
D0F6YM
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Drug Name |
Vamorolone
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Synonyms |
vamorolone; 13209-41-1; UNII-8XP29XMB43; VBP-15; 8XP29XMB43; CHEMBL2348780; 17,21-Dihydroxy-16alpha-methylpregna-1,4,9(11)-triene-3,20-dione; A-Methyl-9,11-dehydro Prednisolone; (8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one; Vamorolone [USAN]; VBP-15 free alcohol; VBP 15; EINECS 236-177-8; AC1MHYKY; Vamorolone (USAN/INN); SCHEMBL143459; GTPL9247; A)-17,21-dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione; ZINC33650317
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Indication | Duchenne muscular dystrophy [ICD-11: 8C70.1] | Approved | [1] | |
Duchenne dystrophy [ICD-11: 8C70; ICD-10: G71.0] | Phase 2 | [2], [3] | ||
Inflammatory bowel disease [ICD-11: DD72; ICD-10: K50-K52] | Phase 1 | [4] | ||
Multiple sclerosis [ICD-11: 8A40; ICD-9: 340] | Phase 1 | [4] | ||
Rheumatoid arthritis [ICD-11: FA20] | Phase 1 | [4] | ||
Company |
Santhera
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Structure |
Download2D MOL |
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Formula |
C22H28O4
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Canonical SMILES |
CC1CC2C3CCC4=CC(=O)C=CC4(C3=CCC2(C1(C(=O)CO)O)C)C
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InChI |
1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1
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InChIKey |
ZYTXTXAMMDTYDQ-DGEXFFLYSA-N
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CAS Number |
CAS 13209-41-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Glucocorticoid receptor messenger RNA (GCR mRNA) | Target Info | Agonist | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
NetPath Pathway | IL2 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Signaling events mediated by HDAC Class II | ||||
FOXA2 and FOXA3 transcription factor networks | ||||
Glucocorticoid receptor regulatory network | ||||
Regulation of Androgen receptor activity | ||||
AP-1 transcription factor network | ||||
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
SIDS Susceptibility Pathways | ||||
Endoderm Differentiation | ||||
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Adipogenesis | ||||
Circadian Clock | ||||
Nuclear Receptors |
References | Top | |||
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REF 1 | FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 215239 | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 3 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
REF 4 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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