Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F8JO
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| Former ID |
DNC007296
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| Drug Name |
4-((+/-)-(1H-imidazol-1-yl)-(E)-retinoic acid
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| Synonyms |
CHEMBL57765; 4-((+/-)-(1H-imidazol-1-yl)-(E)-retinoic acid; SCHEMBL1234027; 4-(1-Imidazolyl)retinoic acid; BDBM50091698; (2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H30N2O2
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| Canonical SMILES |
CC1=C(C(CCC1N2C=CN=C2)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
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| InChI |
1S/C23H30N2O2/c1-17(7-6-8-18(2)15-22(26)27)9-10-20-19(3)21(11-12-23(20,4)5)25-14-13-24-16-25/h6-10,13-16,21H,11-12H2,1-5H3,(H,26,27)/b8-6+,10-9+,17-7+,18-15+
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| InChIKey |
MRFBVQCSZMKBFY-UBFIAYEVSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cytochrome P450 26 (CYP26A1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Retinol metabolism | |||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Metapathway biotransformation | ||||
| Oxidation by Cytochrome P450 | ||||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Adipogenesis | ||||
| Phase 1 - Functionalization of compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and pros... J Med Chem. 2004 Dec 30;47(27):6716-29. | |||
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