Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0F9SG
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| Former ID |
DAP001224
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| Drug Name |
Dexfenfluramine
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| Synonyms |
DEXFENFLURAN; Dexfenfluramine (INN); Redux (TN); (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine; (S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Withdrawn from market | [1] | |
| Therapeutic Class |
Appetite Depressants
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| Company |
Wyeth Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C12H16F3N
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| Canonical SMILES |
CCNC(C)CC1=CC(=CC=C1)C(F)(F)F
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| InChI |
1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1
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| InChIKey |
DBGIVFWFUFKIQN-VIFPVBQESA-N
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| CAS Number |
CAS 3239-44-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:439329
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| SuperDrug ATC ID |
A08AA04
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| SuperDrug CAS ID |
cas=003239449
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Serotonin transporter (SERT) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Serotonergic synapse | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
| 5HT2 type receptor mediated signaling pathway | ||||
| 5HT3 type receptor mediated signaling pathway | ||||
| 5HT4 type receptor mediated signaling pathway | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| NRF2 pathway | ||||
| Synaptic Vesicle Pathway | ||||
| Serotonin Transporter Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. | |||
| REF 2 | Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67(1):27-55. | |||
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