Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0FN7I
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| Former ID |
DNC006211
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| Drug Name |
Des-bromoaplysamine-1
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| Synonyms |
des-bromoaplysamine-1; CHEMBL204377; BDBM50177732; SY246342; MFCD30297079 (95%); 3-[4-[2-(Dimethylamino)ethyl]phenoxy-2,6-D2]-N,N-dimethyl-1-propanamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H26N2O
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| Canonical SMILES |
CN(C)CCCOC1=CC=C(C=C1)CCN(C)C
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| InChI |
1S/C15H26N2O/c1-16(2)11-5-13-18-15-8-6-14(7-9-15)10-12-17(3)4/h6-9H,5,10-13H2,1-4H3
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| InChIKey |
DXZMBOOTLSIFGN-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Aplysamine-1 and related analogs as histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):897-900. | |||
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