Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FS8K
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| Drug Name |
Biphenyl carboxamidopropanoic acid derivative 3
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| Synonyms |
PMID25828189-Compound-8
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| Drug Type |
Small molecular drug
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| Company |
JANSSEN PHARMACEUTICA NV CHAKRAVARTY, Devraj GRECO, Michael, N. SHOOK, Brian XU, Guozhang ZHANG, Rui
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| Structure |
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Download2D MOL |
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| Formula |
C30H26Cl2N2O3
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| Canonical SMILES |
CC(C1=C(C=C(C=C1)Cl)C2=CC=C(C=C2)C(=O)NCCC(=O)O)NC3=CC=C(C=C3)C4=CC=C(C=C4)Cl
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| InChI |
1S/C30H26Cl2N2O3/c1-19(34-26-13-8-21(9-14-26)20-6-10-24(31)11-7-20)27-15-12-25(32)18-28(27)22-2-4-23(5-3-22)30(37)33-17-16-29(35)36/h2-15,18-19,34H,16-17H2,1H3,(H,33,37)(H,35,36)
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| InChIKey |
VTPFIFMNWSMPMA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glucagon receptor (GCGR) | Target Info | Antagonist | [1] |
| Target's Patent Info | Glucagon receptor (GCGR) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glucagon signaling pathway | ||||
| Reactome | Glucagon signaling in metabolic regulation | |||
| G alpha (q) signalling events | ||||
| G alpha (s) signalling events | ||||
| Glucagon-type ligand receptors | ||||
| WikiPathways | GPCRs, Class B Secretin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Integration of energy metabolism | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecule glucagon receptor antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Jul;25(7):819-30. | |||
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