Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FS9K
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| Former ID |
DIB003157
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| Drug Name |
MINAMESTANE
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| Synonyms |
FCE-24928; Minamestane; 4-Aminoandrosta-1,4,6-triene-3,17-dione
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| Drug Type |
Small molecular drug
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| Indication | Bladder cancer [ICD-11: 2C94; ICD-9: 188] | Terminated | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H23NO2
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| Canonical SMILES |
CC12CCC3C(C1CCC2=O)C=CC4=C(C(=O)C=CC34C)N
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| InChI |
1S/C19H23NO2/c1-18-10-8-15(21)17(20)14(18)4-3-11-12-5-6-16(22)19(12,2)9-7-13(11)18/h3-4,8,10-13H,5-7,9,20H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
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| InChIKey |
DAKHYLIFCYPHQW-KZQROQTASA-N
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| CAS Number |
CAS 105051-87-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aromatase (CYP19A1) | Target Info | Inhibitor | [2], [3] |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Estradiol biosynthesis II | ||||
| Estradiol biosynthesis I | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolic pathways | ||||
| Ovarian steroidogenesis | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Androgen/estrogene/progesterone biosynthesis | |||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Reactome | Endogenous sterols | |||
| WikiPathways | Metapathway biotransformation | |||
| Tryptophan metabolism | ||||
| Oxidation by Cytochrome P450 | ||||
| Ovarian Infertility Genes | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| FSH signaling pathway | ||||
| Integrated Breast Cancer Pathway | ||||
| Phase 1 - Functionalization of compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002545) | |||
| REF 2 | High-performance liquid chromatographic determination of FCE 24928, a new aromatase inhibitor, in human plasma. J Chromatogr A. 1994 Feb 4;660(1-2):293-8. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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